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. 1977 Apr 1;145(4):793-801.
doi: 10.1084/jem.145.4.793.

T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells

M Feldmann, P C Beverley, J Woody, I F McKenzie

T-T interactions in the induction of suppressor and helper T cells: analysis of membrane phenotype of precursor and amplifier cells

M Feldmann et al. J Exp Med. .

Abstract

The Ly and Ia phenotypes of T lymphocytes involved in the in vitro generation of helper and suppressor cells were identified. The precursors of both cells are found in adult thymectomized spleen. Helper precursors are Ly-1+2-3-Ia-, while suppressor precursors are Ly-1-2+3+Ia-, although the suppressor effector is Ia+. In both cases a second 'amplifier' cell is required for differentiation of precursors to occur. This cell is found in anti-lymphocyte serum-treated spleen and has the phenotype Ly-1+2+3+Ia-.

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