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. 1984 Mar;25(3):366-7.
doi: 10.1128/AAC.25.3.366.

Prophylaxis of Candida albicans infection in neutropenic mice with liposome-encapsulated amphotericin B

Prophylaxis of Candida albicans infection in neutropenic mice with liposome-encapsulated amphotericin B

G Lopez-Berestein et al. Antimicrob Agents Chemother. 1984 Mar.

Abstract

The efficacy of liposome-encapsulated amphotericin B in the prophylaxis of disseminated Candida albicans infections in neutropenic mice was studied. The administration of liposome-encapsulated amphotericin B was associated with protection against infection with C. albicans when used at doses of greater than or equal to 2 mg of amphotericin B per kg of body weight. Neither empty liposomes nor free amphotericin B showed prophylactic efficacy.

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