Potentiating action of hexoprenaline on 14C-aminopyrine uptake by isolated rat parietal cells
- PMID: 6723912
- DOI: 10.1007/BF01952394
Potentiating action of hexoprenaline on 14C-aminopyrine uptake by isolated rat parietal cells
Abstract
Hexoprenaline potentiated the 14C-aminopyrine uptake (a reliable index of H+ generation) of isolated rat gastric cells stimulated by 10(-6) -10(-4) mol/l carbachol, and inhibited that in response to 10(-4) mol/l histamine without and in the presence of propranolol. It is concluded that hexoprenaline acts as a partial agonist on parietal cell H2-receptors and that beta-adrenoceptor activation may functionally modulate gastric acid secretion.
Similar articles
-
Adrenergic stimulation of isolated rat gastric mucosal cells. Effect on adenylate cyclase and 14C-aminopyrine uptake.Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):175-81. doi: 10.1007/BF00506318. Naunyn Schmiedebergs Arch Pharmacol. 1982. PMID: 7121615
-
Aminopyrine uptake by guinea pig gastric mucosal cells. Mediation by cyclic AMP and interactions among secretagogues.Biochim Biophys Acta. 1981 Jul 17;675(3-4):416-26. doi: 10.1016/0304-4165(81)90035-0. Biochim Biophys Acta. 1981. PMID: 6268193
-
Secretagogue-induced [14C]aminopyrine uptake in isolated equine parietal cells.Am J Vet Res. 1994 Jan;55(1):132-7. Am J Vet Res. 1994. PMID: 7511358
-
H2-receptor antagonism by a novel compound IT-066 assessed from [14C]aminopyrine accumulation in rabbit parietal cells.Eur J Pharmacol. 1990 Mar 27;178(3):343-50. doi: 10.1016/0014-2999(90)90113-k. Eur J Pharmacol. 1990. PMID: 1971222
-
Regulation of gastric acid secretion.Annu Rev Physiol. 1979;41:35-53. doi: 10.1146/annurev.ph.41.030179.000343. Annu Rev Physiol. 1979. PMID: 219762 Review.