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. 1984 May 15;40(5):489-90.
doi: 10.1007/BF01952400.

A new model of glucocorticoid-induced metanephric maldevelopment

E D Avner, W E Sweeney Jr, N P Piesco, D Ellis

A new model of glucocorticoid-induced metanephric maldevelopment

E D Avner et al. Experientia. .

Abstract

A new experimental model of glucocorticoid-induced tubular cyst formation has been developed in metanephric organ culture. The addition of cortisol (1.4 X 10(-5) M) to chemically defined serum-free culture medium produces cystic changes during in vitro nephrogenesis . The model isolates the role of glucocorticoids in experimental cyst formation.

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