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. 1984 May 25;175(3):419-23.
doi: 10.1016/0022-2836(84)90358-9.

Short oligodeoxynucleotides with d(G-C)n sequence do not assume left-handed conformation in high salt conditions

F Quadrifoglio, G Manzini, N Yathindra

Short oligodeoxynucleotides with d(G-C)n sequence do not assume left-handed conformation in high salt conditions

F Quadrifoglio et al. J Mol Biol. .

Abstract

d(G-C)n oligodeoxynucleotides (with n varying from 3 to 7) were studied by the circular dichroism technique in 5 M-NaCl. Contrary to what was previously found with the d(C-G)n series in the same solvent, the left-handed double-stranded Z-conformation appears less stable than the B-form for low n values. The influence of base sequence on the relative stability of B- and Z-conformations for the two series is discussed.

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