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. 1984 May 25;12(10):4051-61.
doi: 10.1093/nar/12.10.4051.

In situ activation of bis-dialkylaminophosphines--a new method for synthesizing deoxyoligonucleotides on polymer supports

A D Barone, J Y Tang, M H Caruthers
Free PMC article

In situ activation of bis-dialkylaminophosphines--a new method for synthesizing deoxyoligonucleotides on polymer supports

A D Barone et al. Nucleic Acids Res. .
Free PMC article

Abstract

Deoxynucleoside phosphoramidites can be prepared in good yield from deoxynucleosides, bis- dialkylaminophosphines , and the corresponding dialkylamine hydrotetrazolide or tetrazole as catalysts. These phosphoramidites generated in situ lead to the direct synthesis of deoxyoligonucleotides on polymer supports.

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References

    1. Nucleic Acids Res. 1981 Jun 25;9(12):2807-17 - PubMed
    1. J Mol Biol. 1975 Dec 5;99(2):237-61 - PubMed

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