[Histological and autoradiographic studies of the objective characterization of the degree of dysplasia in the urothelium]

Abstract

282 biopsy specimens of tumorous and tumor-free urinary bladders have been examined by histological and autoradiographical means. There is no recommendation unified on an international scale for the histological classification of intra-urothelial cell and nucleus abnormities . The classification into three degrees of dysplasia is proposed. The exact characterization of urothelium requires additional objective methods. The increase of the average labeling index parallel to the increasing degree of dysplasia has been proved autoradiographically. Moreover, the change of proliferation pattern with the increasing degree of dysplasia points to the loss of physiological regeneration.