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Case Reports
. 1984 Jul;144(7):1474-7.

Serum inhibitor in systemic lupus erythematosus associated with aplastic anemia

B J Brooks Jr, H E Broxmeyer, C F Bryan, S H Leech
  • PMID: 6732407
Case Reports

Serum inhibitor in systemic lupus erythematosus associated with aplastic anemia

B J Brooks Jr et al. Arch Intern Med. 1984 Jul.

Abstract

Hematologic complications of systemic lupus erythematosus (SLE) usually involve peripheral destruction of blood elements. We report a case of SLE-associated aplastic anemia in which an IgG complement-dependent antibody, obtained from the patient's disease-phase serum but not remission-phase serum, suppressed growth of granulocyte-macrophage progenitor cells from bone marrow of normal donors in vitro. Therapy with plasmapheresis and immunosuppression resulted in lasting remission.

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