Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Jun;27(6):689-93.
doi: 10.1002/art.1780270613.

Susceptibility and resistance to 6-sulfanilamidoindazole-induced arthritis among inbred strains of rats

C O Samuelson Jr, M M Griffiths, J L Mathews, D O Clegg, J R Ward

Susceptibility and resistance to 6-sulfanilamidoindazole-induced arthritis among inbred strains of rats

C O Samuelson Jr et al. Arthritis Rheum. 1984 Jun.

Abstract

Inflammation induced by 6- sulfanilamidoindazole (6-SAI) in aged, outbred rats is predictably produced, but the pathogenesis is not understood. We demonstrate the variable resistance of 15 inbred rat strains to 6-SAI arthritis. Susceptibility to 6-SAI arthritis is not directly linked to the major histocompatibility complex, although resistance is related to the major histocompatibility complex in other experimental forms of rat arthritis. The genetic background of these inbred rat strains appears to have a major role in 6-SAI arthritis susceptibility.

PubMed Disclaimer

Publication types

LinkOut - more resources