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. 1984;26(3):371-3.
doi: 10.1007/BF00548769.

Rapid onset of an increase in caffeine residence time in young women due to oral contraceptive steroids

E C Rietveld, M M Broekman, J J Houben, T K Eskes, J M van Rossum

Rapid onset of an increase in caffeine residence time in young women due to oral contraceptive steroids

E C Rietveld et al. Eur J Clin Pharmacol. 1984.

Abstract

Oral contraceptive steroids increased the residence time of caffeine in 9 young women by a factor of 2. The effect was already manifested during the first cycle 2 weeks after starting oral contraceptive steroids (OCS) and was slightly increased in the second cycle, after 6 weeks on OCS. Toxic effects attributed to oral contraceptive steroids may in part be indirect and due to prolonged retention of absorbed toxic agents to which women are exposed.

PIP: Oral contraceptives (OCs) increased the residence time of caffeine in 9 young women by a factor of 2. The effect was already manifested during the 1st cycle 2 weeks after beginning OCs and was slightly increased in the 2nd cycle, after 6 weeks on OCs. Toxic effects attributed to OCs may in part be indirect and due to prolonged retention of absorbed toxic agents to which women are exposed.

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