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. 1984 May;35(5):412-4.
doi: 10.1016/0020-708x(84)90053-x.

Application of sodium stannite in the preparation of instant [99mTc]HIDA kit

N H Agha, A M Al-Hilli, N D Dahir

Application of sodium stannite in the preparation of instant [99mTc]HIDA kit

N H Agha et al. Int J Appl Radiat Isot. 1984 May.

Abstract

A rapid method for the production of freeze-dried kit containing 20 mg HIDA and 0.4 mg SnCl2 X 2H2O at pH 5.5-6.0 was developed using the stannite procedure. The Sn-HIDA ligand has been prepared successfully by dissolving HIDA in stannite solution without further pH adjustment. A gelchromatography column scanning (GCS) technique has been applied to study the chemical state of technetium in the preparation. The shelf-life of the freeze-dried powder of Sn-HIDA was found stable for at least 6 months as assessed by the GCS-technique. The hepatobiliary agent has a rapid blood clearance and is excreted predominantly by the hepatobiliary system. The biodistribution study in mice showed that more than 30% of the injected dose has been accumulated in liver at 5 min postinjection and at 30 min most of the injected activity has been passed to the intestine via the biliary system.

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