Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984;12(2):151-7.
doi: 10.1016/s0092-1157(84)80048-7.

A biphasic serum glucose response in mice to inoculation with pertussis vaccine

J G Kreeftenberg, I van Straaten-van de Kappelle, D J de Wildt, J B Terligen, W J Peters, H C Walvoort

A biphasic serum glucose response in mice to inoculation with pertussis vaccine

J G Kreeftenberg et al. J Biol Stand. 1984.

Abstract

The effect of B. pertussis vaccine on the serum glucose level of mice was investigated. The results show that at least two components in the vaccine interfere with glucose metabolism. A heat-stable component which is assumed to be LPS induced hypoglycemia 3-5.5 h after inoculation, especially in LPS-sensitized mice. A heat-labile component which is possibly equivalent with the LPF/HSF/IAP complex, is responsible for persistence of the hypoglycaemia for at least 6 days. If hypoglycaemia contributes to the neurological side effects after pertussis vaccination both components have to be considered as being responsible for these effects.

PubMed Disclaimer

LinkOut - more resources