Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Mar-Apr;47(2):270-8.
doi: 10.1021/np50032a006.

Studies of the Thymelaeaceae II. Antineoplastic principles of Gnidia kraussiana

R P Borris, G A Cordell

Studies of the Thymelaeaceae II. Antineoplastic principles of Gnidia kraussiana

R P Borris et al. J Nat Prod. 1984 Mar-Apr.

Abstract

The acetone and methanol extracts of Gnidia kraussiana roots displayed activity against the P-388 lymphocytic leukemia. Bioactivity-directed fractionation led to the isolation of five daphnane orthoesters , all possessing potent antineoplastic activity. Four of these isolates, gnidilatin (1), gnidilatidin (2), Excoecaria toxin (3), and Pimelea factor P2 (4) have been isolated previously from plants in the Thymelaeaceae and Euphorbiaceae. The fifth compound, kraussianin (5), is a new member of the macrocyclic daphnane orthoester series of compounds.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources