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. 1978 Jun;5(6):1955-70.
doi: 10.1093/nar/5.6.1955.

Base pairing structure in the poly d(G-T) double helix: wobble base pairs

T A Early, J Olmsted 3rd, D R Kearns, A G Lezius
Free PMC article

Base pairing structure in the poly d(G-T) double helix: wobble base pairs

T A Early et al. Nucleic Acids Res. 1978 Jun.
Free PMC article

Abstract

High resolution nuclear magnetic resonance (NMR) and ethidium bromide binding studies are used to demonstrate that poly d(G-T) forms an ordered double helical structure at low temperatures (below 24 degrees C in 0.3 M NaCl) in which G and T are hydrogen bonded together in a wobble base pair hydrogen bonding scheme as proposed earlier by Lezius and Domin. Alternative hydrogen bonding schemes involving the tautomeric form of either T or G, such as have been proposed to account for mutation rates in DNA synthesis, are eliminated.

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References

    1. Prog Nucleic Acid Res Mol Biol. 1976;18:91-149 - PubMed
    1. Biochemistry. 1977 Feb 8;16(3):541-51 - PubMed
    1. Biochemistry. 1977 Aug 9;16(16):3647-54 - PubMed
    1. Biopolymers. 1977 Jun;16(6):1331-42 - PubMed
    1. Nucleic Acids Res. 1975 Dec;2(12):2329-41 - PubMed

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