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. 1984 Aug 10;225(4662):636-9.
doi: 10.1126/science.6740330.

Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor

S F Josephs, L Ratner, M F Clarke, E H Westin, M S Reitz, F Wong-Staal

Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor

S F Josephs et al. Science. .

Abstract

The nucleotide sequence of a transforming human c-sis complementary DNA shows an open reading frame 723 base pairs in length located downstream from an in-phase terminator thymine-guanine-adenine codon. Sequences within this region were identical to those previously determined for the exons of the normal human c-sis gene. Thus, the predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for normal human platelet-derived growth factor chain A.

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