Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Jul;18(1):21-5.
doi: 10.1111/j.1365-2125.1984.tb05016.x.

Pharmacodynamics and pharmacokinetics of digoxin in the presence of lithium

S J Cooper, J G Kelly, G D Johnston, S Copeland, D J King, D G McDevitt

Pharmacodynamics and pharmacokinetics of digoxin in the presence of lithium

S J Cooper et al. Br J Clin Pharmacol. 1984 Jul.

Abstract

Previous biochemical and clinical data suggest there may be an interaction between digoxin and lithium. The pharmacodynamics and pharmacokinetics of an intravenous infusion of digoxin were studied in six male subjects before and after 2 weeks treatment with lithium carbonate. The effects of lithium on sodium pump activity, intracellular electrolytes and extracellular electrolytes were studied. No significant interaction between digoxin and lithium was found. No significant effects of lithium on sodium pump activity or electrolyte concentrations were found.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Br J Psychiatry. 1965 Dec;111(481):1133-42 - PubMed
    1. Am J Psychiatry. 1976 Apr;133(4):440-3 - PubMed
    1. Circ Res. 1976 Jul;39(1):1-7 - PubMed
    1. Am J Cardiol. 1976 Nov 23;38(6):701-8 - PubMed
    1. Psychol Med. 1976 May;6(2):257-63 - PubMed

LinkOut - more resources