doi: 10.1007/BF00390992.
Dose-response study of urinary bladder carcinogenesis in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine
- PMID: 6746710
- PMCID: PMC12253724
- DOI: 10.1007/BF00390992
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Dose-response study of urinary bladder carcinogenesis in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine
J Cancer Res Clin Oncol.
1984.
Abstract
A dose-response study was carried out in male F344 rats with a specific urinary bladder carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), which was administered as a solution in drinking water for up to 112 weeks. BBN was given in four different concentrations, 50, 10, 5, and 1 ppm, to groups of 30 rats. The highest dose induced urinary bladder cancer in all rats treated by week 91, decreasing yields being associated with lower dose levels: an incidence of 76.7% was observed with 10 ppm, followed by 20.0% with 5 ppm. The lowest dose (1 ppm) only induced two cases of papilloma (6.9%).
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References
-
- Akagi G, Akagi A, Kimura M, Otsuka H (1973) Comparison of bladder tumors induced in rats and mice with N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann 64:331–336 - PubMed
-
- Althoff J, Pour P, Grandjean C, Eagen M (1976) Transplacental effects of nitrosamines in Syrian hamsters. I. Dibutylnitrosamine and nitrosohexamethyleneamine. Z Krebsforsch 86:69–75 - PubMed
-
- Bertram J, Craig AW (1972) Specific induction of bladder cancer in mice by butyl-(4-hydroxybutyl)nitrosamine and the effects of hormonal modifications on the sex difference in response. Eur J Cancer 8:587–594 - PubMed
-
- Druckrey H, Schildbach A, Schmähl D, Preussmann R, Ivankovic S (1963) Quantitative Analyse der carcinogenen Wirkung von Diäthylnitrosamin. Arzneimittelforsch 13:841–846 - PubMed
-
- Druckrey H, Preussmann R, Ivankovic S, Schmidt CH, Mennel HD, Stahl KW (1964) Selektive Erzeugung von Blasenkrebs an Ratten durch Dibutyl- und N-Butyl-N-Butano(4)-Nitrosamin. Z Krebsforsch 66:280–290 - PubMed
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