Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984;108(1):169-73.
doi: 10.1007/BF00390992.

Dose-response study of urinary bladder carcinogenesis in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine

N Ito, T Shirai, S Fukushima, M Hirose

Dose-response study of urinary bladder carcinogenesis in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine

N Ito et al. J Cancer Res Clin Oncol. 1984.

Abstract

A dose-response study was carried out in male F344 rats with a specific urinary bladder carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), which was administered as a solution in drinking water for up to 112 weeks. BBN was given in four different concentrations, 50, 10, 5, and 1 ppm, to groups of 30 rats. The highest dose induced urinary bladder cancer in all rats treated by week 91, decreasing yields being associated with lower dose levels: an incidence of 76.7% was observed with 10 ppm, followed by 20.0% with 5 ppm. The lowest dose (1 ppm) only induced two cases of papilloma (6.9%).

PubMed Disclaimer

References

    1. Akagi G, Akagi A, Kimura M, Otsuka H (1973) Comparison of bladder tumors induced in rats and mice with N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann 64:331–336 - PubMed
    1. Althoff J, Pour P, Grandjean C, Eagen M (1976) Transplacental effects of nitrosamines in Syrian hamsters. I. Dibutylnitrosamine and nitrosohexamethyleneamine. Z Krebsforsch 86:69–75 - PubMed
    1. Bertram J, Craig AW (1972) Specific induction of bladder cancer in mice by butyl-(4-hydroxybutyl)nitrosamine and the effects of hormonal modifications on the sex difference in response. Eur J Cancer 8:587–594 - PubMed
    1. Druckrey H, Schildbach A, Schmähl D, Preussmann R, Ivankovic S (1963) Quantitative Analyse der carcinogenen Wirkung von Diäthylnitrosamin. Arzneimittelforsch 13:841–846 - PubMed
    1. Druckrey H, Preussmann R, Ivankovic S, Schmidt CH, Mennel HD, Stahl KW (1964) Selektive Erzeugung von Blasenkrebs an Ratten durch Dibutyl- und N-Butyl-N-Butano(4)-Nitrosamin. Z Krebsforsch 66:280–290 - PubMed

Publication types

LinkOut - more resources