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. 1984 Aug;51(2):567-9.
doi: 10.1128/JVI.51.2.567-569.1984.

Mutations in the hemagglutinin receptor-binding site can change the biological properties of an influenza virus

C W Naeve, V S Hinshaw, R G Webster

Mutations in the hemagglutinin receptor-binding site can change the biological properties of an influenza virus

C W Naeve et al. J Virol. 1984 Aug.

Abstract

Avian influenza virus reassortants containing human influenza virus hemagglutinins do not replicate in ducks. Two mutations in the receptor-binding site of a human hemagglutinin at residues 226 and 228 allowed replication in ducks. The mutations resulted in a receptor-binding-site sequence identical to the known avian influenza virus sequences.

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References

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