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. 1977 May 14;1(8020):1029-31.
doi: 10.1016/s0140-6736(77)91260-0.

Isolation of amyloid P component (protein AP) from normal serum as a calcium-dependent binding protein

M B Pepys, A C Dash

Isolation of amyloid P component (protein AP) from normal serum as a calcium-dependent binding protein

M B Pepys et al. Lancet. .

Abstract

The P component of amyloid (protein AP, pentagonal unit) has been isolated from normal serum by using its hitherto undescribed calcium-dependent affinity for agarose. The presence of P component in all forms of amyloid may be due to this calcium-dependent binding to certain polyanions.

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