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Clinical Trial
. 1982 Sep;43(9):369-71.

Amoxapine and amitriptyline: serum levels and clinical response in patients with primary unipolar depression

M A Click Jr, S Zisook
  • PMID: 6749828
Clinical Trial

Amoxapine and amitriptyline: serum levels and clinical response in patients with primary unipolar depression

M A Click Jr et al. J Clin Psychiatry. 1982 Sep.

Abstract

Amoxapine, a new antidepressant of the dibenzoxazepine class, was compared with amitriptyline in 80 patients with primary unipolar depressive disorders. In a four-week double-blind trial, the two medications were equally effective and had similar onsets of therapeutic action. The range of side effects was similar, although there was a trend for fewer side effects in the amoxapine group. Serum levels were not related to therapeutic response for either medication.

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