doi: 10.1126/science.6750791.
Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi
- PMID: 6750791
- DOI: 10.1126/science.6750791
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Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi
Science.
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Abstract
Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide-linked enzymes (alpha-hydroxyacid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture.
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