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. 1982 Oct 15;218(4569):288-9.
doi: 10.1126/science.6750791.

Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi

E E Montamat, C Burgos, N M Gerez de Burgos, L E Rovai, A Blanco, E L Segura

Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi

E E Montamat et al. Science. .

Abstract

Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide-linked enzymes (alpha-hydroxyacid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture.

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