Effects of prostacyclin and prostaglandin E2 on the secretion of pancreatic juice in the dog

Abstract

1. Effects of prostacyclin (PGI2) and prostaglandin E2 (PGE2) on the secretion of pancreatic juice were investigated in preparations of the blood-perfused canine pancreas. 2. PGI2 did not affect the basal or secretin-induced pancreatic secretion. However, PGE2 caused a dose-related inhibition of the secretin-induced secretion not only in preparations of the constant pressure perfusion but also of the constant flow perfusion. 3. These results suggest that PGE2, but not PGI2, may control the secretory mechanism of the pancreatic secretion in dogs.