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. 1982:7:81-6.

Demonstration of a S-methyl metabolite of captopril in patients undergoing chronic captopril therapy

O H Drummer, B Jarrott, W J Louis
  • PMID: 6754187

Demonstration of a S-methyl metabolite of captopril in patients undergoing chronic captopril therapy

O H Drummer et al. Clin Exp Pharmacol Physiol Suppl. 1982.

Abstract

1. The formation of the S-methyl metabolite of captopril has been demonstrated for the first time in the urine of five patients receiving chronic captopril therapy. 2. Patients were studied following a 100 mg oral dose of captopril. 3. Excretion values for S-methylcaptopril were 0.66 mg and 0.31 mg at 0-3 h and 3-6 h postdose. Captopril excretion was at these two collections 15.5 mg and 2.3 mg, respectively.

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