Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Dec;77(4):591-6.
doi: 10.1111/j.1476-5381.1982.tb09336.x.

Pinane thromboxane A2 analogues are non-selective prostanoid antagonists in rat and human stomach muscle

A Bennett, G J Sanger

Pinane thromboxane A2 analogues are non-selective prostanoid antagonists in rat and human stomach muscle

A Bennett et al. Br J Pharmacol. 1982 Dec.

Abstract

1 Pinane thromboxane A2 (PTxA2) and its epi-OH isomer were studied on rat and human stomach longitudinal muscle. 2 PTxA2 (0.5 micrograms/ml) usually caused a slight contraction of rat gastric fundus. Contractions to PGE2, PGF2 alpha, PGI2 and epoxymethano analogues of PGH2 (U-46619 and U-44069) were substantially inhibited, whereas those to PGD2 and acetylcholine were only slightly reduced. 3 In human stomach, PTxA2 0.5 micrograms/ml rarely stimulated the muscle. Contractions to PGE2, PGF2 alpha and U-46619 were antagonized, with little effect on those to acetylcholine. 4 epi-PTxA2 (0.5 micrograms/ml) did not affect rat gastric tone. It was moderately potent against PGI2 on rat gastric fundus, but was less effective than PTxA2 against U-44069.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Nature. 1969 Jul 12;223(5202):208-10 - PubMed
    1. Adv Drug Res. 1974;8:83-118 - PubMed
    1. Prostaglandins. 1977 Jul;14(1):11-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Jun;76(6):2566-70 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Aug;76(8):4097-101 - PubMed

Publication types

LinkOut - more resources