doi: 10.1002/eji.1830121116.
Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody
- PMID: 6759145
- DOI: 10.1002/eji.1830121116
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Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody
Eur J Immunol.
1982 Nov.
Abstract
The anti-pan T cell monoclonal antibody OKT3 was administered daily for 2 weeks in four human renal allograft recipients. The antibody induced a dramatic and immediate depletion of peripheral T cells followed by an in vivo antigenic modulation of the OKT3-defined membrane antigen: after three injections, OKT3-treated patients showed a limited but significant number of OKT3- cells of T cell nature (as defined by OKT4 and OKT8) which recovered the OKT3 receptor after an overnight in vitro incubation in the absence of the monoclonal antibody.
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