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. 1982 Nov;12(11):979-82.
doi: 10.1002/eji.1830121116.

Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody

L Chatenoud, M F Baudrihaye, H Kreis, G Goldstein, J Schindler, J F Bach

Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody

L Chatenoud et al. Eur J Immunol. 1982 Nov.

Abstract

The anti-pan T cell monoclonal antibody OKT3 was administered daily for 2 weeks in four human renal allograft recipients. The antibody induced a dramatic and immediate depletion of peripheral T cells followed by an in vivo antigenic modulation of the OKT3-defined membrane antigen: after three injections, OKT3-treated patients showed a limited but significant number of OKT3- cells of T cell nature (as defined by OKT4 and OKT8) which recovered the OKT3 receptor after an overnight in vitro incubation in the absence of the monoclonal antibody.

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