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. 1982 Dec;102(4):665-77.
doi: 10.1093/genetics/102.4.665.

PEP4 gene function is required for expression of several vacuolar hydrolases in Saccharomyces cerevisiae

E W Jones, G S Zubenko, R R Parker

PEP4 gene function is required for expression of several vacuolar hydrolases in Saccharomyces cerevisiae

E W Jones et al. Genetics. 1982 Dec.

Abstract

The pep4-3 mutation results in a 90-95% reduction in the levels of five vacuolar hydrolases in yeast, including proteinases A and B, carboxypeptidase Y, RNase(s) and the repressible alkaline phosphatase. The mutation is without effect on two secreted glycoproteins, on an enzyme of the vacuolar membrane, and on a proteinase located outside of the vacuole. Mutations at the PEP4 locus exhibit a dosage effect on the levels of some, but not all, of the enzymes whose expression requires the function of the gene.

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