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Clinical Trial
. 1980;1(2-3):125-36.

Indomethacin treatment in patent ductus arteriosus. A double-blind study utilizing indomethacin plasma levels

R M Nestrud, D E Hill, R W Arrington, A G Beard, W T Dungan, P Y Lau, J B Norton, R I Readinger
  • PMID: 6765467
Clinical Trial

Indomethacin treatment in patent ductus arteriosus. A double-blind study utilizing indomethacin plasma levels

R M Nestrud et al. Dev Pharmacol Ther. 1980.

Abstract

23 premature infants were placed on a randomized double-blind study to evaluate the effectiveness of indomethacin in closing a patent ductus arteriosus. Infants received 0.2 mg/kg indomethacin or placebo by gavage. In the treatment group, 7 patients responded out of a total of 12, while in the placebo group, 2 responded out of a total of 11. Indomethacin plasma levels were obtained in 6 patients in the treatment group. Plasma levels showed marked variability in peak level (60-3,100 ng/ml), time to peak level (0.5-6 h) and t1/2 (1 to greater than 24 h).

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