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. 1980 Jan 19;280(6208):145-7.
doi: 10.1136/bmj.280.6208.145.

Evidence that type I diabetes and thyrogastric autoimmunity have different genetic determinants

A N Gorsuch, B M Dean, G F Bottazzo, J Lister, A G Cudworth

Evidence that type I diabetes and thyrogastric autoimmunity have different genetic determinants

A N Gorsuch et al. Br Med J. .

Abstract

The prevalences of autoimmune endocrine disease and relevant organ-specific autoantibodies were determined in 141 patients with type I (insulin-dependent) diabetes and their families. All available members of the families were genotyped for HLA. Islet-cell antibody was found in 10 (4%) out of 248 unaffected siblings, all of whom were genetically potential cases of diabetes. One developed classical symptoms six months later. In contrast, thyroid and gastric parietal-cell antibodies occurred independent of the HLA-linked susceptibility to diabetes. These results suggest that different genes control the production of these autoantibodies and the susceptibility to type I diabetes.

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