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. 1980 Feb;77(2):919-23.
doi: 10.1073/pnas.77.2.919.

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch

T Kataoka, T Kawakami, N Takahashi, T Honjo

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch

T Kataoka et al. Proc Natl Acad Sci U S A. 1980 Feb.

Abstract

Cloning and nucleotide sequence determination suggest that the rearranged gamma 1-chain gene in a gamma 1-chain-producing myeloma a-pears to be formed by the recombination between the 5' flanking regions of the gamma 1- and mu-chain genes of undifferentiated cells. The recombination site is distinct from the putative J region and is a novel region that we call the S region. We have extended our previous model that explains the heavy-chain class switching by two or more successive recombination events.

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References

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