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. 1980 Apr 25;255(8):3691-4.

Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes

Y Nishioka, P Leder
  • PMID: 6767723
Free article

Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes

Y Nishioka et al. J Biol Chem. .
Free article

Abstract

We have determined the entire sequence of two immunoglobulin kappa variable region genes derived separately from embryonic and plasmacytoma cells. Both genes are in the germline configuration; both are organized into hydrophobic leader and mature V-region coding sequences separated by a short intervening sequence. Both are identical with one another throughout the 1360 bases determined. In addition, there is a simple repeat sequence of 31 CA doublets that occurs about 300 bases from the 3' side of the coding sequence in each gene.

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