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. 1980 May;30(5):557-9.
doi: 10.1212/wnl.30.5.557-a.

Protein binding of valproic acid in uremic patients

J Bruni, L H Wang, T C Marbury, C S Lee, B J Wilder

Protein binding of valproic acid in uremic patients

J Bruni et al. Neurology. 1980 May.

Abstract

Protein binding of valproic acid was studied in four uremic patients on long-term hemodialysis. Before dialysis, the free fraction was 0.31 +/- 0.11 (SD); this was larger than in nonuremic subjects. During hemodialysis, the free fraction increased significantly (p less than 0.01) in three patients (mean, 0.64 +/- 0.32 SD).

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