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. 1980 Apr 15;36(4):441-2.
doi: 10.1007/BF01975136.

Increase of collagen synthesis in pulmonary arteries of monocrotaline-treated rats

R Kameji, H Otsuka, Y Hayashi

Increase of collagen synthesis in pulmonary arteries of monocrotaline-treated rats

R Kameji et al. Experientia. .

Abstract

Collagen synthesis in the pulmonary artery in animals with pulmonary hypertension was studied using monocrotaline-treated rats as a model. Incorporation of 14C-lateled proline into collagenase-digestible protein in the pulmonary artery was found to be 4-5 times higher in monocrotaline-treated rats than in control rats.

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