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. 1980 Apr;41(4):630-5.
doi: 10.1038/bjc.1980.106.

Time dependence of the in vitro cytotoxicity of hexamethylmelamine and its metabolites

M D'Incalci, E Erba, G Balconi, L Morasca, S Garattini
Free PMC article

Time dependence of the in vitro cytotoxicity of hexamethylmelamine and its metabolites

M D'Incalci et al. Br J Cancer. 1980 Apr.
Free PMC article

Abstract

The cytotoxicity of hexamethylmelamine (HMM) and its metabolites pentamethylmelamine (PMM), N,2,2,4,6-tetramethylmelamine (TMM) and hydroxymethylpentamethylmelamine (HMPMM) and of the alkylating agent triethylenemelamine (TEM) were studied on a cell line derived from a human ovarian cancer, by measuring [3H]TdR uptake. After 24 h of incubation all the tested compounds inhibited [3H]TdR uptake, but only at a concentration of 100 micrograms/ml. However, after 120 h incubation, concentrations of 0.1--10 micrograms/ml resulted in highly significant cytotoxicity. HMPMM and TEM were the most active and their effect was not reversed 72 h after their removal. In our in vitro system no metabolism of HMM was observed.

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