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. 1980;68(1):105-7.
doi: 10.1007/BF00426658.

Effect of intraperitoneally administered GABA on haloperidol-induced catalepsy in the rat

J J Balsara, J H Jadhav, A G Chandorkar

Effect of intraperitoneally administered GABA on haloperidol-induced catalepsy in the rat

J J Balsara et al. Psychopharmacology (Berl). 1980.

Abstract

Pretreatment with GABA (250--1,000 mg/kg IP) potentiated the cataleptogenic effect of haloperidol in a dose-dependent manner in rats. GABA (GABA, B.D.H. Ltd.) alone in a dose of 2,000 mg/kg (IP) also induced catalepsy. The results may be due to partial access of blood-borne GABA to the CNS, leading to inhibition of nigro-striatal dopaminergic neurons involved in the functioning of the corpus striatum.

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