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Comparative Study
. 1980;69(1):35-7.
doi: 10.1007/BF00426518.

Comparative enzyme-inducing effects of chlorpromazine and fluphenazine therapies in psychotic patients

A W Harman, D B Frewin, B G Priestly
Comparative Study

Comparative enzyme-inducing effects of chlorpromazine and fluphenazine therapies in psychotic patients

A W Harman et al. Psychopharmacology (Berl). 1980.

Abstract

Antipyrine elimination kinetics were measured in psychotic patients receiving either long-term chlorpromazine or fluphenazine decanoate therapy and in non-medicated control subjects. Patients receiving chlorpromazine metabolised antipyrine faster than the controls while, in patients receiving fluphenazine decanoate, there was not change. The results suggest that long-term chlorpromazine therapy induced the activity of drug-metabolising enzymes, whereas fluphenazine decanoate therapy had no effect.

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