doi: 10.1007/BF01978589.
Monoamine oxidase inhibitors and histamine metabolism
- PMID: 6772465
- DOI: 10.1007/BF01978589
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Monoamine oxidase inhibitors and histamine metabolism
Experientia.
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Abstract
In rat, histamine metabolism is altered by some nonspecific inhibitors of monoamine oxidase (MAO) such as iproniazid, and, to a lesser extent, tranylcypromine. Type A MAO inhibitors, such as clorgyline and MD780515, do not seem to interfere with the metabolism of histamine. Deprenyl, a type B MAO inhibitor, shows some inhibition which is, however, much lower than that observed with iproniazid. The strong effect of iproniazid is probably due to its DAO inhibiting properties.
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