Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Jul 15;36(7):818-10.
doi: 10.1007/BF01978589.

Monoamine oxidase inhibitors and histamine metabolism

M S Benedetti, J F Ancher, N Sontag

Monoamine oxidase inhibitors and histamine metabolism

M S Benedetti et al. Experientia. .

Abstract

In rat, histamine metabolism is altered by some nonspecific inhibitors of monoamine oxidase (MAO) such as iproniazid, and, to a lesser extent, tranylcypromine. Type A MAO inhibitors, such as clorgyline and MD780515, do not seem to interfere with the metabolism of histamine. Deprenyl, a type B MAO inhibitor, shows some inhibition which is, however, much lower than that observed with iproniazid. The strong effect of iproniazid is probably due to its DAO inhibiting properties.

PubMed Disclaimer

References

    1. Pharmacol Rev. 1966 Dec;18(4):1163-99 - PubMed
    1. J Pharm Belg. 1977 May-Jun;32(3):264-303 - PubMed
    1. J Pharmacol Exp Ther. 1949 Jan;95(1):71-8 - PubMed
    1. Br J Pharmacol. 1978 Sep;64(1):109-22 - PubMed
    1. Biochem Pharmacol. 1962 Mar;11:177-82 - PubMed