doi: 10.1038/286776a0.
RNA splicing generates a variant light chain from an aberrantly rearranged kappa gene
- PMID: 6772972
- DOI: 10.1038/286776a0
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RNA splicing generates a variant light chain from an aberrantly rearranged kappa gene
Nature.
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Abstract
Both C kappa regions in MPC 11 cells are rearranged into active transcripion units, one producing a normal kappa chain and the other an internally deleted kappa fragment lacking a V region. The gene coding for the kappa fragment mRNA is aberrantly rearranged and lacks a site for V leads to C kappa splicing. An alternative splicing event which deletes the V region from the nuclear RNA precursor generates the kappa fragment mRNA.
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