doi: 10.1126/science.6773144.
Gap junction development is correlated with insulin content in the pancreatic B cell
- PMID: 6773144
- DOI: 10.1126/science.6773144
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Gap junction development is correlated with insulin content in the pancreatic B cell
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Abstract
The development of gap junctions between insulin-containing B cells was quantitatively analyzed in islets of Langerhans isolated from rats treated with the sulfonylurea glibenclamid for 1, 2, or 7 days. Glibenclamid treatment was associated with a marked depletion of the insulin content of B cells and with an increase in the number and size of gap junctions between these cells. A significance correlation was found between these two events.
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