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. 1980 Aug 14;286(5774):676-83.
doi: 10.1038/286676a0.

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

H Sakano, R Maki, Y Kurosawa, W Roeder, S Tonegawa

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

H Sakano et al. Nature. .

Abstract

At least two types of somatic recombination are necessary for the generation of a complete immunoglobulin gamma 2b gene from germ-line DNA sequences. The first type of recombination consists of the assembly of three separate DNA segments, each encoding a different part of the variable region. The second type of recombination replaces the exons coding for the constant region of the mu chain with those coding for the same region of the gamma 2b chain. The DNA sequencing studies suggest that the two types of recombination operate by different mechanisms.

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