Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980;10(2):125-31.
doi: 10.1007/BF01561561.

Chromosome segregation and expression of rat immunoglobulins in rat/mouse hybrid myelomas

J Schröder, K Autio, J M Jarvis, C Milstein

Chromosome segregation and expression of rat immunoglobulins in rat/mouse hybrid myelomas

J Schröder et al. Immunogenetics. 1980.

Abstract

The chromosome segregation of hybrid myelomas from a fusion of rat immunized spleen cells and the mouse myeloma P3-X63-Ag8 has been analysed. Chromosome loss appears to be nonrandom. Most mouse chromosomes are retained. The rat chromosome are preferentially lost but a few--particularly 1-5 and 13--are rarely lost. The specific retention of some rat chromosomes explains the stability of rat Ig expression in mouse-rat hybrids. Correlation of chromosome loss and retention and loss of rat heavy and light chains leads us to propose chromosome 14 as coding for the heavy chain.

PubMed Disclaimer

References

    1. Eur J Immunol. 1976 Apr;6(4):292-5 - PubMed
    1. Somatic Cell Genet. 1978 Jan;4(1):45-54 - PubMed
    1. Immunol Rev. 1979;47:139-74 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Jul;75(7):3367-71 - PubMed
    1. Cold Spring Harb Symp Quant Biol. 1977;41 Pt 2:793-803 - PubMed

Substances

LinkOut - more resources