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Comparative Study
. 1980 May;19(5):671-82.
doi: 10.1016/0090-6980(80)90166-5.

Piroxicam, a structurally novel anti-inflammatory compound. Mode of prostaglandin synthesis inhibition

T J Carty, J S Stevens, J G Lombardino, M J Parry, M J Randall
Comparative Study

Piroxicam, a structurally novel anti-inflammatory compound. Mode of prostaglandin synthesis inhibition

T J Carty et al. Prostaglandins. 1980 May.

Abstract

Piroxicam is a potent inhibitor of prostaglandin biosynthesis. Experiments utilizing cell culture and microsomes derived from various sources have demonstrated that piroxicam is a selective inhibitor of the cyclooxygenase step of arachidonic acid metabolism. Little blocking activity is observed at the phospholipase, thromboxane or prostacyclin synthetase, and arachidonic acid lipoxygenase steps.

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