The analgesic effect of intravenous indoprofen and lysine acetylsalicylate in patients with postoperative pain

Abstract

Indoprofen, as isoindolinyl derivative, was evaluated as a postoperative analgesic in a randomized double-blind, between-patients study on 40 men with postgastrectomy pain. Single intravenous doses of 100 and 300 mg indoprofen and 0.5 and 1.5 Gm lysine acetylsalicylate (ASA) were compared in a four-point assay. The method of evaluation relied on subjective appraisal of pain relief by the patient for 6 hours after medication. The results demonstrate the analgesic efficacy of indoprofen in patients with severe postoperative pain, a dose-dependent effect, and a 13-to-16 potency ratio to ASA as judged from total pain relief.