doi: 10.1038/287603a0.
Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma
- PMID: 6776411
- DOI: 10.1038/287603a0
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Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma
Nature.
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Abstract
Leader, variable (V) and joining (J) gene segments, and adjacent regions of two rearranged alleles of the same kappa-chain producing mouse myeloma, comprising approximately 3,200 base pairs, have been sequenced. Sequence comparisons are reported. V-J joining in one of the alleles leads to a reading frame with a stop codon within the J-gene segments. Allelic exclusion is apparently realized in this tumour through the formation of such a non-functional allele.
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