Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Nov;30(2):496-9.
doi: 10.1128/iai.30.2.496-499.1980.

Suppression of antibody responses in humans infected with Trypanosoma cruzi

D S Cunningham, M Grogl, R E Kuhn

Suppression of antibody responses in humans infected with Trypanosoma cruzi

D S Cunningham et al. Infect Immun. 1980 Nov.

Abstract

Peripheral blood leukocytes from patients serologically positive for Chagas' disease were examined for their ability to respond to heterologous antigens in vitro. It was found that mononuclear cells from chagasic patients had greatly reduced ability to respond to sheep erythrocytes (SRBC) as compared with peripheral blood mononuclear cells (PBMC) from control subjects. The reduction in anti-SRBC antibody activity was independent of antigen dose and was not a result of differences in antibody response kinetics. Depletion of plastic-adherent result of differences in antibody response kinetics. Depletion of plastic-adherent cells from the PBMC of patients did not affect the suppressed state of the nonadherent lymphocytes. No relationship was evident between the duration of Trypanosoma cruzi infection and the degree of humoral responsiveness.

PubMed Disclaimer

References

    1. Rev Inst Med Trop Sao Paulo. 1966 Sep-Oct;8(5):227-35 - PubMed
    1. Scand J Clin Lab Invest Suppl. 1968;97:77-89 - PubMed
    1. Cell Immunol. 1972 Feb;3(2):264-76 - PubMed
    1. Transplant Rev. 1974;18:130-91 - PubMed
    1. Exp Parasitol. 1975 Jun;37(3):417-25 - PubMed

Publication types