Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980;18(1):57-64.
doi: 10.1007/BF01324374.

The combined action of chemical carcinogens on DNA repair in human cells

F E Ahmed

The combined action of chemical carcinogens on DNA repair in human cells

F E Ahmed. Radiat Environ Biophys. 1980.

Abstract

Excision repair was studied in normal human and ataxia telangiectasia (AT) cells proficient in repair of UV and its mimetic chemicals, and in xeroderma pigmentosum group C (XP C) cells (deficient in repair of UV and its mimetics), after treatment with several combinations of chemical carcinogens, by the photolysis of bromodeoxyuridine incorporated into parental DNA during repair. Results indicate that repair was additive in AT, and XP C cells treated with N-acetoxy-2-acetylaminofluorene (AAAF) plus ethyl methanesulfonate (EMS) or methyl methanesulfonate (MMS) indicating that there are different rate limiting steps for removal of both types of damage. Data on the combinations of 4-nitroquinoline 1-oxide (4NQO) plus MMS or EMS are difficult to interpret, but they do not indicate inhibition of DNA repair.

PubMed Disclaimer

References

    1. Biophys J. 1970 Mar;10(3):237-45 - PubMed
    1. Nature. 1971 Feb 5;229(5284):416-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1971 Apr;68(4):708-12 - PubMed
    1. Radiat Res. 1978 Dec;76(3):441-58 - PubMed
    1. Cancer Res. 1974 Dec;34(12):3318-25 - PubMed

MeSH terms