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. 1977 Mar;7(1):57-61.
doi: 10.1007/BF01964881.

The modulation of histamine release by alpha-adrenoceptors: evidences in murine neoplastic mast cells

F Moroni, R Fantozzi, E Masini, P F Mannaioni

The modulation of histamine release by alpha-adrenoceptors: evidences in murine neoplastic mast cells

F Moroni et al. Agents Actions. 1977 Mar.

Abstract

Murine neoplastic mast cells which have been loaded with exogenous labelled histamine, released 14C-histamine when exposed to increasing concentrations of phenylephrine and noradrenaline. Adrenaline was only slightly effective, while isoprenaline and dibutyryl-cyclic-AMP were fully inactive. The release of histamine evoked by alpha-adrenergic agonists was antagonized by phentolamine, and left unchanged by practolol and cocaine. It is concluded that alpha-adrenoceptors may be valuable in evoking histamine release by murine neoplastic mast cells.

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References

    1. J Immunol. 1974 Feb;112(2):511-9 - PubMed
    1. Agents Actions. 1975 Dec;5(5):417-23 - PubMed
    1. J Physiol. 1962 Nov;164:210-26 - PubMed
    1. N Engl J Med. 1973 Aug 9;289(6):277-81 - PubMed
    1. Biochem Pharmacol. 1975 Feb 15;24(4):538-40 - PubMed

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