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. 1980 Dec 1;152(6):1817-22.
doi: 10.1084/jem.152.6.1817.

Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control

G H Sunshine, D R Katz, M Feldmann

Dendritic cells induce T cell proliferation to synthetic antigens under Ir gene control

G H Sunshine et al. J Exp Med. .

Abstract

Dendritic cells prepared by a modification of the method of Steinman and Cohn are I-A+ and FcR-. They are extremely potent at activating not only allogeneic T cell proliferation but also antigen-specific syngeneic T cell proliferation. Dendritic cells from nonresponder strains are unable to present antigens to responder X nonresponder T cells, suggesting that they may be a site of Ir gene product expression.

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