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Comparative Study
. 1980 Nov;77(11):6734-8.
doi: 10.1073/pnas.77.11.6734.

Evolutionary approach to the question of immunoglobulin heavy chain switching: evidence from cloned human and mouse genes

J V Ravetch, I R Kirsch, P Leder
Comparative Study

Evolutionary approach to the question of immunoglobulin heavy chain switching: evidence from cloned human and mouse genes

J V Ravetch et al. Proc Natl Acad Sci U S A. 1980 Nov.

Abstract

We have used cloned mouse and human heavy chain genes to identify regions of conserved homology between mouse and man and between mu and alpha genes. Using heteroduplex mapping, we find that coding segments for homologous domains appear to have been well conserved between the two species, but the short intervening sequences that separate domains have diverged considerably. These studies also identify extensive regions of homology 5' to both mu and alpha constant region genes that are conserved between the two genes as well as between mouse and man. These segments encompass regions in which mu/alpha recombination occurs during the heavy chain class switch, and their extensive homology may be relevant to this process.

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References

    1. Cell. 1980 Oct;21(3):793-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1965 Sep;54(3):864-9 - PubMed
    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. Annu Rev Genet. 1975;9:305-53 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3628-32 - PubMed

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